翻訳と辞書 Words near each other ・ Non-combatant evacuation operation ・ Non-commercial ・ Non-commercial advertising ・ Non-commercial educational ・ Non-commissioned member ・ Non-commissioned officer ・ Non-Commissioned Officer Academy ・ Non-Commissioned Officer in Charge ・ Non-Commissioned Officer Professional Development Ribbon ・ Non-communicable disease ・ Non-communications signals ・ Non-commutative conditional expectation ・ Non-commutative cryptography ・ Non-compact stencil ・ Non-compete clause ・ Non-competitive antagonist ・ Non-competitive inhibition ・ Non-configurational language ・ Non-conforming loan ・ Non-conforming mortgage ・ Non-conformists of the 1930s ・ Non-constituency Member of Parliament ・ Non-constructive algorithm existence proofs ・ Non-consultant hospital doctor ・ Non-contact atomic force microscopy ・ Non-contact force ・ Non-contact thermography ・ Non-contact ultrasound ・ Non-contact wafer testing ・ Non-conventional trademark Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Non-competitive antagonist ： ウィキペディア英語版 Non-competitive antagonist The term "non-competitive antagonism" (sometimes called non-surmountable antagonists) can be used to describe two distinct phenomena: one in which the antagonist binds to the active site of the receptor, and one in which the antagonist binds to an allosteric site of the receptor. While the mechanism of antagonism is different in both of these phenomena, they are both called "non-competitive" because the end-results of each are functionally very similar. Unlike competitive antagonists, which affect the amount of agonist necessary to achieve a maximal response but do not affect the magnitude of that maximal response, non-competitive antagonists reduce the magnitude of the maximum response that can be attained by any amount of agonist. This property earns them the name "non-competitive" because their effects cannot be negated, no matter how much agonist is present. In functional assays of non-competitive antagonists, depression of the maximal response of agonist dose-response curves, and in some cases, rightward shifts, is produced. The rightward shift will occur as a result of a receptor reserve (also known as spare receptors)〔 of the original article.〕 and inhibition of the agonist response will only occur when this reserve is depleted. An antagonist that binds to the active site of a receptor is said to be "non-competitive" if the bond between the active site and the antagonist is irreversible or nearly so.〔 This usage of the term "non-competitive" may not be ideal, however, since the term "irreversible competitive antagonism" may also be used to describe the same phenomenon without the potential for confusion with the second meaning of "non-competitive antagonism" discussed below. The second form of "non-competitive antagonists" act at an allosteric site.〔 These antagonists bind to a distinctly separate binding site from the agonist, exerting their action to that receptor via the other binding site. They do not compete with agonists for binding at the active site. The bound antagonists may prevent conformational changes in the receptor required for receptor activation after the agonist binds.〔D.E. Golan, A.H Tashjian Jr, E.J. Armstrong, A.W. Armstrong. (2007) Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy Lippincott Williams & Wilkins ISBN 0-7817-8355-0〕 Cyclothiazide has been shown to act as a reversible non-competitive antagonist of mGluR1 receptor. == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Non-competitive antagonist」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.